![]() The study period of 1998 to 2001 was chosen because that particular screening round was the tenth year since the inception of BTW. BTW received notifications of all BCs diagnosed as well as any deaths that occurred during follow-up. All women aged 50–65 years who attended breast screening between April 1998 and April 2001 were followed up for ≥10 years. 12 That study revalidated the value of the NPI in segregating BCs into groups with varying prognoses.īTW holds a carefully maintained central database for all cancers diagnosed in women who have attended breast screening. 11 The most recently updated survival data a vailable with reference to the NPI are related to consecutive BCs and BC-specific survival in a single centre in Nottingham ( Table 1). In comparison, calculation of the NPI is simpler, requires fewer data, and can more easily provide gross projection of survival.įive- and ten-year survival from BC in the UK has been reported to be 85% 10 and 77%, respectively. 1, 6– 9ĪO, in contrast, is an Internet-based analytical tool used to project the outcomes of patients with or without adjuvant therapy based on epidemiology, tumour characteristics, estimated efficacy of endocrine therapy or chemotherapy and, finally, a Bayesian statistical method to predict the long-term prognosis. ![]() The NPI has been applied to prospective validation in multiple centres with comparable results. It is, therefore, used as a surrogate marker of aggressiveness of BCs. Since then, the NPI has been refined and segregates patients into four groups, and is used to predict five-year survival (in accordance with the more commonly used time scales for survival of other types of cancers). The NPI was used to predict survival of 80%, 42% and 13% in three groups of patients according to the NPI score. The NPI takes into account the size of the tumour, number of lymph nodes involved, and tumour grade. ![]() Commonly used prognostic indicators include the Nottingham Prognostic Index (NPI), 1– 3 and the Internet-based Adjuvant! Online (AO). ![]() Multiple prognostication models are available within the UK. Prognostication of breast cancers (BCs) helps clinicians in decision-making by using information to stratify risk and tailor individual treatment plans. ![]()
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